The talks' objective would be to find a way for Assad to leave power with the "minimum of bloodshed and destruction", al-Khatib said in a statement published on his Facebook page.
He also offered to create a “liberated land in northern Syria” if the regime was so concerned about sovereignty and preferred to stay within Syrian borders.
Mr. al-Khatib said earlier he was open for negotiations with Assad’s deputy Farouq al-Shara that could pave the way towards a dialogue with the government.
The move was praised by the UN, with the organization’s top foreign official chief Jeffrey Feltman describing it as “the most promising thing we've heard on Syria recently”. He said the UN and Arab League’s peace envoy Lakhdar Brahimi were exploring how to use al-Khatib’s offer to find solution to the Syrian crisis.
International Syria envoy Lakhdar Brahimi has met in Cairo with head of the National Coalition of the Syrian Opposition Ahmed Moaz al-Khatib to discuss Khatib’s avowed readiness to accept peace talks provided the Syrian government releases all women and all 160,000 opposition supporters held in Syrian jails.
Brahimi also held talks on Sunday with Arab League Secretary General Nabil El-Arabi on the “latest developments of the Syrian crisis and the possible efforts to resolve it,” KUNA news agency reported.
In late January, Al-Khatib, a leader of the National Coalition of Syrian Revolutionary and Opposition Forces (SNCROF), said he was ready to start talks with Syrian authorities, but demanded the release of 160,000 prisoners and the extension of expired passports for Syrians living outside the country.
He later said the dialogue will not start if all women being held in Syrian prisons are not released by February 10.
The Syrian government said earlier this week it is open for dialogue with the opposition, but without any preconditions.
Syria has been locked in an increasingly bloody civil war since demonstrations broke out against President Bashar al-Assad in March 2011. According to UN estimates, at least 60,000 people have been killed in the conflict.
Voice of Russia, Reuters, RIA